Bitiscetin-3, a Novel C-Type Lectin-like Protein Cloned from the Venom Gland of the Viper <i>Bitis arietans</i>, Induces Platelet Agglutination and Inhibits Binding of Von Willebrand Factor to Collagen

Bitiscetin-3, a Novel C-Type Lectin-like Protein Cloned from the Venom Gland of the Viper <i>Bitis arietans</i>, Induces Platelet Agglutination and Inhibits Binding of Von Willebrand Factor to Collagen

Bitiscetin-1 (aka bitiscetin) and bitiscetin-2 are C-type lectin-like proteins purified from the venom of <i>Bitis arietans</i> (puff adder). They bind to von Willebrand factor (VWF) and—at least bitiscetin-1—induce platelet agglutination via enhancement of VWF binding to platelet glycop...

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Bibliographic Details
Main Authors: Youhei Nashimoto, Fumio Matsushita, Johannes M. Dijkstra, Yuta Nakamura, Hidehiko Akiyama, Jiharu Hamako, Takashi Morita, Satohiko Araki, Taei Matsui
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Toxins
Subjects:
bitiscetin
von Willebrand factor
platelet agglutination
snake venom
GPIb
collagen
Online Access:https://www.mdpi.com/2072-6651/14/4/236

Internet

https://www.mdpi.com/2072-6651/14/4/236

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