Loss-of-function/gain-of-function polymorphisms of the ATP sensitive P2X7R influence sepsis, septic shock, pneumonia, and survival outcomes

Loss-of-function/gain-of-function polymorphisms of the ATP sensitive P2X7R influence sepsis, septic shock, pneumonia, and survival outcomes

IntroductionExtracellular ATP (eATP) released from damaged cells activates the P2X7 receptor (P2X7R) ion channel on the surface of surrounding cells, resulting in calcium influx, potassium efflux and inflammasome activation. Inherited changes in the P2X7R gene (P2RX7) influence eATP induced response...

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Bibliographic Details
Main Authors: Johanna Guggemos, Stephen J. Fuller, Kristen K. Skarratt, Benjamin Mayer, E. Marion Schneider
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Immunology
Subjects:
P2RX7
loss-of-function (LOF)
gain-of-function (GOF) single nucleotide polymorphisms (SNP)
linkage disequilibrium
pneumonia
sepsis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1352789/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1352789/full

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