Cell-specific gain modulation by synaptically released zinc in cortical circuits of audition

In many excitatory synapses, mobile zinc is found within glutamatergic vesicles and is coreleased with glutamate. Ex vivo studies established that synaptically released (synaptic) zinc inhibits excitatory neurotransmission at lower frequencies of synaptic activity but enhances steady state synaptic...

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Bibliographic Details
Main Authors: Charles T Anderson, Manoj Kumar, Shanshan Xiong, Thanos Tzounopoulos
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/29893