A Factor XIa Inhibitor Engineered from Banded Krait Venom Toxin: Efficacy and Safety in Rodent Models of Arterial and Venous Thrombosis

Activated factor XI (FXIa) is an important antithrombotic drug target. Clinical and pre-clinical data have demonstrated that its inhibition attenuates thrombosis with minimal risk of excessive bleeding. We isolated Fasxiator from the venom of banded krait <i>Bungarus fasciatus</i> and su...

詳細記述

書誌詳細
主要な著者: Wei Seng Chng, Aaron Wei Liang Li, Jasmine Jia Min Lim, Esther Jia En Leong, Fathiah S. Amran, R. Manjunatha Kini, Mark Yan Yee Chan, Cho Yeow Koh
フォーマット: 論文
言語:English
出版事項: MDPI AG 2022-07-01
シリーズ:Biomedicines
主題:
オンライン・アクセス:https://www.mdpi.com/2227-9059/10/7/1679