Androgen receptor-mediated pharmacogenomic expression quantitative trait loci: implications for breast cancer response to AR-targeting therapy

Androgen receptor-mediated pharmacogenomic expression quantitative trait loci: implications for breast cancer response to AR-targeting therapy

Abstract Background Endocrine therapy is the most important treatment modality of breast cancer patients whose tumors express the estrogen receptor α (ERα). The androgen receptor (AR) is also expressed in the vast majority (80–90%) of ERα-positive tumors. AR-targeting drugs are not used in clinical...

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Bibliographic Details
Main Authors: Huanyao Gao, Lixuan Wei, Shreya Indulkar, Thanh Thanh. L. Nguyen, Duan Liu, Ming-Fen Ho, Cheng Zhang, Hu Li, Richard M. Weinshilboum, James N. Ingle, Liewei Wang
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Breast Cancer Research
Subjects:
PGx-eQTL
Breast cancer
Endocrine therapy
Aromatase inhibitor
GWAS
Pharmacogenomics
Online Access:https://doi.org/10.1186/s13058-024-01861-2

Internet

https://doi.org/10.1186/s13058-024-01861-2

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