The inhibition of assembly of HIV-1 virus-like particles by 3-<it>O</it>-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain
<p>Abstract</p> <p>Background</p> <p>DSB, the 3-<it>O</it>-(3',3'dimethylsuccinyl) derivative of betulinic acid, blocks the last step of protease-mediated processing of HIV-1 Gag precursor (Pr55Gag), which leads to immature, noninfectious virions....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-12-01
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| Series: | Virology Journal |
| Online Access: | http://www.virologyj.com/content/5/1/162 |