The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity

The anti-inflammatory cytokine interleukin-37 is an inhibitor of trained immunity

Summary: Trained immunity (TI) is a de facto innate immune memory program induced in monocytes/macrophages by exposure to pathogens or vaccines, which evolved as protection against infections. TI is characterized by immunometabolic changes and histone post-translational modifications, which enhance...

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Bibliographic Details
Main Authors: Giulio Cavalli, Isak W. Tengesdal, Mark Gresnigt, Travis Nemkov, Rob J.W. Arts, Jorge Domínguez-Andrés, Raffaella Molteni, Davide Stefanoni, Eleonora Cantoni, Laura Cassina, Silvia Giugliano, Kiki Schraa, Taylor S. Mills, Eric M. Pietras, Elan Z. Eisenmensser, Lorenzo Dagna, Alessandra Boletta, Angelo D’Alessandro, Leo A.B. Joosten, Mihai G. Netea, Charles A. Dinarello
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
trained immunity
innate immunity
cytokines
IL-1 family
cell energy metabolism
immunometabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002692

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http://www.sciencedirect.com/science/article/pii/S2211124721002692

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