Mechanism Underlying the Bypass of Apurinic/Pyrimidinic Site Analogs by <i>Sulfolobus acidocaldarius</i> DNA Polymerase IV

Mechanism Underlying the Bypass of Apurinic/Pyrimidinic Site Analogs by <i>Sulfolobus acidocaldarius</i> DNA Polymerase IV

The spontaneous depurination of genomic DNA occurs frequently and generates apurinic/pyrimidinic (AP) site damage that is mutagenic or lethal to cells. Error-prone DNA polymerases are specifically responsible for the translesion synthesis (TLS) of specific DNA damage, such as AP site damage, general...

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Bibliographic Details
Main Authors: Qin-Ying Huang, Dong Song, Wei-Wei Wang, Li Peng, Hai-Feng Chen, Xiang Xiao, Xi-Peng Liu
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
AP site analogs
translesion synthesis
Dbh
little finger domain
<i>Sulfolobus acidocaldarius</i>
Online Access:https://www.mdpi.com/1422-0067/23/5/2729

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https://www.mdpi.com/1422-0067/23/5/2729

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