EPCR-PAR1 biased signaling regulates perfusion recovery and neovascularization in peripheral ischemia

EPCR-PAR1 biased signaling regulates perfusion recovery and neovascularization in peripheral ischemia

Blood clot formation initiates ischemic events, but coagulation roles during postischemic tissue repair are poorly understood. The endothelial protein C receptor (EPCR) regulates coagulation, as well as immune and vascular signaling, by protease activated receptors (PARs). Here, we show that endothe...

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Bibliographic Details
Main Authors: Magdalena L. Bochenek, Rajinikanth Gogiraju, Stefanie Großmann, Janina Krug, Jennifer Orth, Sabine Reyda, George S. Georgiadis, Henri M. Spronk, Stavros Konstantinides, Thomas Münzel, John H. Griffin, Philipp Wild, Christine Espinola-Klein, Wolfram Ruf, Katrin Schäfer
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-07-01
Series:JCI Insight
Subjects:
Angiogenesis
Vascular biology
Online Access:https://doi.org/10.1172/jci.insight.157701

Internet

https://doi.org/10.1172/jci.insight.157701

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