Identification of RyR2-PBmice and the effects of transposon insertional mutagenesis of the RyR2 gene on cardiac function in mice

Identification of RyR2-PBmice and the effects of transposon insertional mutagenesis of the RyR2 gene on cardiac function in mice

Ryanodine receptor 2 (RyR2) plays an important role in maintaining the normal heart function, and mutantions can lead to arrhythmia, heart failure and other heart diseases. In this study, we successfully identified a piggyBac translocated RyR2 gene heterozygous mouse model (RyR2-PBmice) by tracking...

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Bibliographic Details
Main Authors: Qianqian Wang, Chao Wang, Bo Wang, Qirui Shen, Leilei Qiu, Shuaijun Zou, Tao Wang, Guoyan Liu, Beilei Wang, Liming Zhang
Format: Article
Language:English
Published: PeerJ Inc. 2019-05-01
Series:PeerJ
Subjects:
RyR2
Piggybac
Cardiomyocyte
Mitochondrion
Ca2+
Online Access:https://peerj.com/articles/6942.pdf

Internet

https://peerj.com/articles/6942.pdf

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