PNPLA3-I148M Variant Promotes the Progression of Liver Fibrosis by Inducing Mitochondrial Dysfunction

PNPLA3-I148M Variant Promotes the Progression of Liver Fibrosis by Inducing Mitochondrial Dysfunction

Patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 polymorphism (I148M) is strongly associated with non-alcoholic steatohepatitis and advanced fibrosis; however, the underlying mechanisms remain largely unknown. In this study, we investigated the effect of PNPLA3-I148M on the activatio...

Full description

Bibliographic Details
Main Authors: Yusong Gou, Lifei Wang, Jinhan Zhao, Xiaoyi Xu, Hangfei Xu, Fang Xie, Yanjun Wang, Yingmei Feng, Jing Zhang, Yang Zhang
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
PNPLA3-I148M
hepatic stellate cells
liver fibrosis
free cholesterol
mitochondrial
Online Access:https://www.mdpi.com/1422-0067/24/11/9681

Internet

https://www.mdpi.com/1422-0067/24/11/9681

Similar Items