The unfolded protein response and the role of protein disulphide isomerase in neurodegeneration.

The maintenance and regulation of proteostasis is a critical function for post-mitotic neurons and dysregulation of proteostasis is increasingly implicated in neurodegenerative diseases. Despite having different clinical manifestations, these disorders share similar pathology; an accumulation of mis...

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Bibliographic Details
Main Authors: Emma ePerri, Colleen eThomas, Sonam eParakh, Damian eSpencer, Julie eAtkin
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00080/full