The unfolded protein response and the role of protein disulphide isomerase in neurodegeneration.

The unfolded protein response and the role of protein disulphide isomerase in neurodegeneration.

The maintenance and regulation of proteostasis is a critical function for post-mitotic neurons and dysregulation of proteostasis is increasingly implicated in neurodegenerative diseases. Despite having different clinical manifestations, these disorders share similar pathology; an accumulation of mis...

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Bibliographic Details
Main Authors:	Emma ePerri, Colleen eThomas, Sonam eParakh, Damian eSpencer, Julie eAtkin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2016-01-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	neurodegeneration Amyotrophic lateral sclerosis (ALS) Alzheimer’s disease (AD) unfolded protein response (UPR) Parkinson’s disease (PD) Protein disulphide isomerase (PDI)
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00080/full

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