Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers

Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers

Chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are incurable hematological malignancies that are pathologically linked with aberrant NF-κB activation. In this study, we identified a group of novel C8-linked benzofused Pyrrolo[2,1-c][1,4]benzodiazepines (PBD) monomeric hybrids capable...

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Bibliographic Details
Main Authors: Thomas Lewis, David B. Corcoran, David E. Thurston, Peter J. Giles, Kevin Ashelford, Elisabeth J. Walsby, Christopher D. Fegan, Andrea G.S. Pepper, Khondaker Miraz Rahman, Chris Pepper
Format: Article
Language:English
Published: Ferrata Storti Foundation 2020-05-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/9748

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https://haematologica.org/article/view/9748

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