Staurosporine and extracellular matrix proteins mediate the conversion of small cell lung carcinoma cells into a neuron-like phenotype.

Staurosporine and extracellular matrix proteins mediate the conversion of small cell lung carcinoma cells into a neuron-like phenotype.

Small cell lung carcinomas (SCLCs) represent highly aggressive tumors with an overall five-year survival rate in the range of 5 to 10%. Here, we show that four out of five SCLC cell lines reversibly develop a neuron-like phenotype on extracellular matrix constituents such as fibronectin, laminin or...

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Bibliographic Details
Main Authors: Tamara Murmann, Carmen Carrillo-García, Nadine Veit, Cornelius Courts, Alexander Glassmann, Viktor Janzen, Burkhard Madea, Markus Reinartz, Anne Harzen, Michael Nowak, Sven Perner, Jochen Winter, Rainer Probstmeier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3938400?pdf=render

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http://europepmc.org/articles/PMC3938400?pdf=render

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