Trehalose Activates Hepatic and Myocardial Autophagy and Has Anti-Inflammatory Effects in <i>db</i>/<i>db</i> Diabetic Mice

Trehalose Activates Hepatic and Myocardial Autophagy and Has Anti-Inflammatory Effects in <i>db</i>/<i>db</i> Diabetic Mice

<i>Db/db</i> mice (carrying a mutation in the gene encoding leptin receptor) show autophagy suppression. Our aim was to evaluate the effect of autophagy inducer trehalose on liver and heart autophagy in <i>db/db</i> mice and to study inflammation dysregulation and the suitabi...

Full description

Bibliographic Details
Main Authors: Tatiana A. Korolenko, Marina V. Ovsyukova, Nataliya P. Bgatova, Igor D. Ivanov, Svetlana I. Makarova, Valentin A. Vavilin, Alexey V. Popov, Ekaterina I. Yuzhik, Elena V. Koldysheva, Erik C. Korolenko, Evgeny L. Zavjalov, Tamara G. Amstislavskaya
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Life
Subjects:
leptin-deficient <i>db/db</i> mice
trehalose
autophagy
inflammatory dysregulation
<i>IL-10</i>
<i>TNF-alpha</i> expression
Online Access:https://www.mdpi.com/2075-1729/12/3/442

Internet

https://www.mdpi.com/2075-1729/12/3/442

Similar Items