Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle

Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle

Summary: MYC proteins bind globally to active promoters and promote transcriptional elongation by RNA polymerase II (Pol II). To identify effector proteins that mediate this function, we performed mass spectrometry on N-MYC complexes in neuroblastoma cells. The analysis shows that N-MYC forms comple...

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Bibliographic Details
Main Authors: Gabriele Büchel, Anne Carstensen, Ka-Yan Mak, Isabelle Roeschert, Eoin Leen, Olga Sumara, Julia Hofstetter, Steffi Herold, Jacqueline Kalb, Apoorva Baluapuri, Evon Poon, Colin Kwok, Louis Chesler, Hans Michael Maric, David S. Rickman, Elmar Wolf, Richard Bayliss, Susanne Walz, Martin Eilers
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717317576

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http://www.sciencedirect.com/science/article/pii/S2211124717317576

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