Increase in the proportion of Plasmodium falciparum with kelch13 C580Y mutation and decline in pfcrt and pfmdr1 mutant alleles in Papua New Guinea

Increase in the proportion of Plasmodium falciparum with kelch13 C580Y mutation and decline in pfcrt and pfmdr1 mutant alleles in Papua New Guinea

Abstract Background The C580Y mutation in the Plasmodium falciparum kelch13 gene is the most commonly observed variant in artemisinin-resistant isolates in the Greater Mekong Subregion (GMS). Until 2017, it had not been identified outside the GMS, except for Guyana/Amazonia. In 2017, three parasites...

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Bibliographic Details
Main Authors: Naoko Yoshida, Masato Yamauchi, Ryosuke Morikawa, Francis Hombhanje, Toshihiro Mita
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Malaria Journal
Subjects:
Plasmodium falciparum
Artemisinin
Chloroquine
Lumefantrine
Resistance
kelch13
Online Access:https://doi.org/10.1186/s12936-021-03933-6

Internet

https://doi.org/10.1186/s12936-021-03933-6

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