Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin

Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin

Background Pressure overload of the heart occurs in patients with hypertension or valvular stenosis and induces cardiac fibrosis because of excessive production of extracellular matrix by activated cardiac fibroblasts. This initially provides essential mechanical support to the heart, but eventually...

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Bibliographic Details
Main Authors: Kate M. Herum, Andreas Romaine, Ariel Wang, Arne Olav Melleby, Mari E. Strand, Julian Pacheco, Bjørn Braathen, Pontus Dunér, Theis Tønnessen, Ida G. Lunde, Ivar Sjaastad, Cord Brakebusch, Andrew D. McCulloch, Maria F. Gomez, Cathrine R. Carlson, Geir Christensen
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
aortic stenosis
cardiac fibroblasts
left ventricular fibrosis
extracellular matrix
mechanical
myofibroblast
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.013518

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.013518

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