Human PD-1hiCD8+ T Cells Are a Cellular Source of IL-21 in Rheumatoid Arthritis

Human PD-1hiCD8+ T Cells Are a Cellular Source of IL-21 in Rheumatoid Arthritis

BackgroundRheumatoid arthritis (RA) is a prototypical autoantibody-driven autoimmune disease in which T-B interactions play a critical role. Recent comprehensive analysis suggests that PD-1+CD8+ T cells as well as two distinct IL-21-producing PD-1+CD4+ T cell subsets, follicular helper T (Tfh) and p...

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Bibliographic Details
Main Authors: Kazuhiko Higashioka, Motoki Yoshimura, Takahide Sakuragi, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Makoto Kikukawa, Hisakata Yamada, Takahiko Horiuchi, Koichi Akashi, Hiroaki Niiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
IL-21
CD8
T cells
PD-1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.654623/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.654623/full

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