Low CD8<sup>+</sup> T Cell Infiltration and High PD-L1 Expression Are Associated with Level of CD44<sup>+</sup>/CD133<sup>+</sup> Cancer Stem Cells and Predict an Unfavorable Prognosis in Pancreatic Cancer

Low CD8<sup>+</sup> T Cell Infiltration and High PD-L1 Expression Are Associated with Level of CD44<sup>+</sup>/CD133<sup>+</sup> Cancer Stem Cells and Predict an Unfavorable Prognosis in Pancreatic Cancer

Cancer immunotherapy targeting immune checkpoints has exhibited promising clinical outcomes in many cancers, but it offers only limited benefits for pancreatic cancer (PC). Cancer stem cells (CSCs), a minor subpopulation of cancer cells, play important roles in tumor initiation, progression, and dru...

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Bibliographic Details
Main Authors: Ya-Chin Hou, Ying-Jui Chao, Min-Hua Hsieh, Hui-Ling Tung, Hao-Chen Wang, Yan-Shen Shan
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
pancreatic cancer
T cells
cancer stem cells
CD8
PD-L1
CD44
CD133
immunotherapy
Online Access:https://www.mdpi.com/2072-6694/11/4/541

Internet

https://www.mdpi.com/2072-6694/11/4/541

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