Mechanisms of Resistance to Photodynamic Therapy (PDT) in Vulvar Cancer

Mechanisms of Resistance to Photodynamic Therapy (PDT) in Vulvar Cancer

Photodynamic therapy (PDT) is a valuable treatment method for vulvar intraepithelial neoplasia (VIN). It allows for the treatment of a multifocal disease with minimal tissue destruction. 5-Aminolevulinic acid (5-ALA) is the most commonly used prodrug, which is converted in the heme pathway to protop...

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Bibliographic Details
Main Authors: Beata Joanna Mossakowska, Somayeh Shahmoradi Ghahe, Dominik Cysewski, Anna Fabisiewicz, Barbara Tudek, Janusz Aleksander Siedlecki
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
photodynamic therapy
photosensitizer
protoporphyrin IX
heme metabolism
multidrug resistance
DNA repair
Online Access:https://www.mdpi.com/1422-0067/23/8/4117

Internet

https://www.mdpi.com/1422-0067/23/8/4117

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