TRANSGENIC GDNF POSITIVELY INFLUENCES PROLIFERATION, DIFFERENTIATION, MATURATION AND SURVIVAL OF MOTOR NEURONS PRODUCED FROM MOUSE EMBRYONIC STEM CELLS.

TRANSGENIC GDNF POSITIVELY INFLUENCES PROLIFERATION, DIFFERENTIATION, MATURATION AND SURVIVAL OF MOTOR NEURONS PRODUCED FROM MOUSE EMBRYONIC STEM CELLS.

Embryonic stem cells (ESC) are pluripotent and thus can differentiate into every cell type present in the body. Directed differentiation into motor neurons has been described for pluripotent cells. Although neurotrophic factors promote neuronal survival, their role in neuronal commitment is elusive....

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Bibliographic Details
Main Authors: Daniel Édgar Cortés, Yolanda Robledo-Arratia, Ricardo Hernández-Martínez, Itzel Escobedo-Avila, Jose Bargas, Ivan Velasco
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Neuroprotection
excitotoxicity
neural precursors
spinal motor neuron
gdnf
Electrophysiological maturation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00217/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00217/full

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