Proteomic clustering reveals the kinetics of disease biomarkers in bovine and human models of post-traumatic osteoarthritis

Proteomic clustering reveals the kinetics of disease biomarkers in bovine and human models of post-traumatic osteoarthritis

Objectives: In this study, we apply a clustering method to proteomic data sets from bovine and human models of post-traumatic osteoarthritis (PTOA) to distinguish clusters of proteins based on their kinetics of release from cartilage and examined these groups for PTOA biomarker candidates. We then q...

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Bibliographic Details
Main Authors: Rebecca Mae Black, Yang Wang, André Struglics, Pilar Lorenzo, Susan Chubinskaya, Alan J. Grodzinsky, Patrik Önnerfjord
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Post-traumatic osteoarthritis
Mass spectrometry
Cartilage matrix
Cytokines
Proteomics
Dexamethasone
Online Access:http://www.sciencedirect.com/science/article/pii/S2665913121000546

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http://www.sciencedirect.com/science/article/pii/S2665913121000546

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