L-Proline Prevents Endoplasmic Reticulum Stress in Microglial Cells Exposed to L-azetidine-2-carboxylic Acid

L-Proline Prevents Endoplasmic Reticulum Stress in Microglial Cells Exposed to L-azetidine-2-carboxylic Acid

L-Azetidine-2-carboxylic acid (AZE) is a non-protein amino acid that shares structural similarities with its proteogenic L-proline amino acid counterpart. For this reason, AZE can be misincorporated in place of L-proline, contributing to AZE toxicity. In previous work, we have shown that AZE induces...

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Bibliographic Details
Main Authors: Jordan Allan Piper, Nour Al Hammouri, Margo Iris Jansen, Kenneth J. Rodgers, Giuseppe Musumeci, Amolika Dhungana, Sahar Masoumeh Ghorbanpour, Laura A. Bradfield, Alessandro Castorina
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
azetidine-2-carboxylic acid
unfolded protein response
endoplasmic reticulum
microglia
multiple sclerosis
L-proline
Online Access:https://www.mdpi.com/1420-3049/28/12/4808

Internet

https://www.mdpi.com/1420-3049/28/12/4808

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