Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease

Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease

Inflammation and fibrosis are important components of diseases that contribute to the malfunction of epithelia and endothelia. The Rho guanine nucleotide exchange factor (GEF) GEF-H1/ARHGEF-2 is induced in disease and stimulates inflammatory and fibrotic processes, cell migration, and metastasis. He...

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Bibliographic Details
Main Authors: Clare Mills, Sandra A. Hemkemeyer, Zerin Alimajstorovic, Chantelle Bowers, Malihe Eskandarpour, John Greenwood, Virginia Calder, A. W. Edith Chan, Paul J. Gane, David L. Selwood, Karl Matter, Maria S. Balda
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cells
Subjects:
RhoA
tight junctions
inflammation
retinal pigment epithelium
endothelium
Online Access:https://www.mdpi.com/2073-4409/11/11/1733

Internet

https://www.mdpi.com/2073-4409/11/11/1733

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