Reconfiguration of the reductive TCA cycle enables high-level succinic acid production by Yarrowia lipolytica

Reconfiguration of the reductive TCA cycle enables high-level succinic acid production by Yarrowia lipolytica

Abstract Succinic acid (SA) is an important C4-dicarboxylic acid. Microbial production of SA at low pH results in low purification costs and hence good overall process economics. However, redox imbalances limited SA biosynthesis from glucose via the reductive tricarboxylic acid (TCA) cycle in yeast....

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Bibliographic Details
Main Authors: Zhiyong Cui, Yutao Zhong, Zhijie Sun, Zhennan Jiang, Jingyu Deng, Qian Wang, Jens Nielsen, Jin Hou, Qingsheng Qi
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44245-4

Internet

https://doi.org/10.1038/s41467-023-44245-4

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