Hepatic patatin‐like phospholipase domain‐containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans

Abstract In nonalcoholic fatty liver disease (NAFLD) the patatin‐like phospholipase domain‐containing 3 (PNPLA3) rs738409 variant is a contributor. In mice, the Pnpla3 148M variant accumulates on lipid droplets and probably leads to sequestration of a lipase cofactor leading to impaired mobilization...

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Bibliographic Details
Main Authors: Elke Ericson, Linnéa Bergenholm, Anne‐Christine Andréasson, Carly I. Dix, Jane Knöchel, Sara F. Hansson, Richard Lee, Jennifer Schumi, Madeleine Antonsson, Ola Fjellström, Patrik Nasr, Mathias Liljeblad, Björn Carlsson, Stergios Kechagias, Daniel Lindén, Mattias Ekstedt
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2022-10-01
Series:Hepatology Communications
Online Access:https://doi.org/10.1002/hep4.2032