Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts
Human transcriptome can undergo RNA mis-splicing due to spliceopathies contributing to the increasing number of genetic diseases including muscular dystrophy (MD), Alzheimer disease (AD), Huntington disease (HD), myelodysplastic syndromes (MDS). Intron retention (IR) is a major inducer of spliceopat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1244377/full |
| _version_ | 1797614344487305216 |
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| author | Bashayer A. Khalifah Bashayer A. Khalifah Shareefa A. Alghamdi Ali H. Alhasan Ali H. Alhasan |
| author_facet | Bashayer A. Khalifah Bashayer A. Khalifah Shareefa A. Alghamdi Ali H. Alhasan Ali H. Alhasan |
| author_sort | Bashayer A. Khalifah |
| collection | DOAJ |
| description | Human transcriptome can undergo RNA mis-splicing due to spliceopathies contributing to the increasing number of genetic diseases including muscular dystrophy (MD), Alzheimer disease (AD), Huntington disease (HD), myelodysplastic syndromes (MDS). Intron retention (IR) is a major inducer of spliceopathies where two or more introns remain in the final mature mRNA and account for many intronic expansion diseases. Potential removal of such introns for therapeutic purposes can be feasible when utilizing bioinformatics, catalytic RNAs, and nano-drug delivery systems. Overcoming delivery challenges of catalytic RNAs was discussed in this review as a future perspective highlighting the significance of utilizing synthetic biology in addition to high throughput deep sequencing and computational approaches for the treatment of mis-spliced transcripts. |
| first_indexed | 2024-03-11T07:11:04Z |
| format | Article |
| id | doaj.art-094194226f154c14b5e54effcf69d95d |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-11T07:11:04Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-094194226f154c14b5e54effcf69d95d2023-11-17T08:35:02ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-11-011110.3389/fbioe.2023.12443771244377Unleashing the potential of catalytic RNAs to combat mis-spliced transcriptsBashayer A. Khalifah0Bashayer A. Khalifah1Shareefa A. Alghamdi2Ali H. Alhasan3Ali H. Alhasan4Institute for Bioengineering, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaFaculty of Sciences, King Abdulaziz University, Jeddah, Saudi ArabiaFaculty of Sciences, King Abdulaziz University, Jeddah, Saudi ArabiaInstitute for Bioengineering, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi ArabiaCollege of Science and General Studies, Alfaisal University, Riyadh, Saudi ArabiaHuman transcriptome can undergo RNA mis-splicing due to spliceopathies contributing to the increasing number of genetic diseases including muscular dystrophy (MD), Alzheimer disease (AD), Huntington disease (HD), myelodysplastic syndromes (MDS). Intron retention (IR) is a major inducer of spliceopathies where two or more introns remain in the final mature mRNA and account for many intronic expansion diseases. Potential removal of such introns for therapeutic purposes can be feasible when utilizing bioinformatics, catalytic RNAs, and nano-drug delivery systems. Overcoming delivery challenges of catalytic RNAs was discussed in this review as a future perspective highlighting the significance of utilizing synthetic biology in addition to high throughput deep sequencing and computational approaches for the treatment of mis-spliced transcripts.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1244377/fullintron retentionsynthetic biologyspliceosomespliceopathiescatalytic RNAs |
| spellingShingle | Bashayer A. Khalifah Bashayer A. Khalifah Shareefa A. Alghamdi Ali H. Alhasan Ali H. Alhasan Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts Frontiers in Bioengineering and Biotechnology intron retention synthetic biology spliceosome spliceopathies catalytic RNAs |
| title | Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts |
| title_full | Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts |
| title_fullStr | Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts |
| title_full_unstemmed | Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts |
| title_short | Unleashing the potential of catalytic RNAs to combat mis-spliced transcripts |
| title_sort | unleashing the potential of catalytic rnas to combat mis spliced transcripts |
| topic | intron retention synthetic biology spliceosome spliceopathies catalytic RNAs |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1244377/full |
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