Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP

Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP

Abstract Background Lamins, key nuclear lamina components, have been proposed as candidate risk biomarkers in different types of cancer but their accuracy is still debated. AKTIP is a telomeric protein with the property of being enriched at the nuclear lamina. AKTIP has similarity with the tumor sus...

Full description

Bibliographic Details
Main Authors: Mattia La Torre, Chiara Merigliano, Klizia Maccaroni, Alexandre Chojnowski, Wah Ing Goh, Maria Giubettini, Fiammetta Vernì, Cristina Capanni, Daniela Rhodes, Graham Wright, Brian Burke, Silvia Soddu, Romina Burla, Isabella Saggio
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Lamins
Nuclear morphology
Protein mislocalization
Risk biomarker
Tumor cells
Progeria mutations
Online Access:https://doi.org/10.1186/s13046-022-02480-5

Internet

https://doi.org/10.1186/s13046-022-02480-5

Similar Items