Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine
TRPV3 mediates cutaneous sensations such as itch and pain. Here authors present the cryo-EM structure of TRPV3 bound with local anesthetic which binds the channel in membrane portals that connect the membrane environment to the channel pore.
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30537-8 |