Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine
TRPV3 mediates cutaneous sensations such as itch and pain. Here authors present the cryo-EM structure of TRPV3 bound with local anesthetic which binds the channel in membrane portals that connect the membrane environment to the channel pore.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30537-8 |
| _version_ | 1818240883714162688 |
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| author | Arthur Neuberger Kirill D. Nadezhdin Alexander I. Sobolevsky |
| author_facet | Arthur Neuberger Kirill D. Nadezhdin Alexander I. Sobolevsky |
| author_sort | Arthur Neuberger |
| collection | DOAJ |
| description | TRPV3 mediates cutaneous sensations such as itch and pain. Here authors present the cryo-EM structure of TRPV3 bound with local anesthetic which binds the channel in membrane portals that connect the membrane environment to the channel pore. |
| first_indexed | 2024-12-12T13:20:31Z |
| format | Article |
| id | doaj.art-094b5acee7a94109b8750bb873c62838 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T13:20:31Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-094b5acee7a94109b8750bb873c628382022-12-22T00:23:19ZengNature PortfolioNature Communications2041-17232022-05-011311910.1038/s41467-022-30537-8Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonineArthur Neuberger0Kirill D. Nadezhdin1Alexander I. Sobolevsky2Department of Biochemistry and Molecular Biophysics, Columbia UniversityDepartment of Biochemistry and Molecular Biophysics, Columbia UniversityDepartment of Biochemistry and Molecular Biophysics, Columbia UniversityTRPV3 mediates cutaneous sensations such as itch and pain. Here authors present the cryo-EM structure of TRPV3 bound with local anesthetic which binds the channel in membrane portals that connect the membrane environment to the channel pore.https://doi.org/10.1038/s41467-022-30537-8 |
| spellingShingle | Arthur Neuberger Kirill D. Nadezhdin Alexander I. Sobolevsky Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine Nature Communications |
| title | Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine |
| title_full | Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine |
| title_fullStr | Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine |
| title_full_unstemmed | Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine |
| title_short | Structural mechanism of TRPV3 channel inhibition by the anesthetic dyclonine |
| title_sort | structural mechanism of trpv3 channel inhibition by the anesthetic dyclonine |
| url | https://doi.org/10.1038/s41467-022-30537-8 |
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