Lactate up-regulates the expression of PD-L1 in kidney and causes immunosuppression in septic Acute Renal Injury
Background: This study aims to explore the mechanism of immunosuppression in septic Acute Renal Injury (AKI) and the role of programmed death-1 (PD-1/PD-L1) pathway in septic AKI. Methods: This study established a septic AKI model by Cecal ligation and puncture (CLP) in C57/B6 mice, ELISA was used t...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-06-01
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Series: | Journal of Microbiology, Immunology and Infection |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1684118219301689 |