Lactate up-regulates the expression of PD-L1 in kidney and causes immunosuppression in septic Acute Renal Injury

Background: This study aims to explore the mechanism of immunosuppression in septic Acute Renal Injury (AKI) and the role of programmed death-1 (PD-1/PD-L1) pathway in septic AKI. Methods: This study established a septic AKI model by Cecal ligation and puncture (CLP) in C57/B6 mice, ELISA was used t...

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Bibliographic Details
Main Authors: Jingjing Xu, Xiaohui Ma, Kaili Yu, Ruitao Wang, Sicong Wang, Ruijin Liu, Haitao Liu, Hong Gao, Kaijiang Yu, Changsong Wang
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Journal of Microbiology, Immunology and Infection
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1684118219301689