Human iPSC-derived retinal organoids develop robust Alzheimer’s disease neuropathology

Human iPSC-derived retinal organoids develop robust Alzheimer’s disease neuropathology

Alzheimer’s disease (AD), characterized by memory loss and cognitive decline, affects nearly 50 million people worldwide. Amyloid beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) of phosphorylated Tau protein (pTau) are key histopathological features of the disease in the brain, an...

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Bibliographic Details
Main Authors: Ethan James, Anne Vielle, Karen Cusato, Helen Li, Byoungin Lee, Shama Parween, Anna Howell, Noah R. Johnson, Heidi J. Chial, Huntington Potter, M. Natalia Vergara
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
hiPSC
retina
organoid
Alzheimer’s disease
disease modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1340448/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2024.1340448/full

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