M1 and M2 Monocytes in Rheumatoid Arthritis: A Contribution of Imbalance of M1/M2 Monocytes to Osteoclastogenesis

M1 and M2 Monocytes in Rheumatoid Arthritis: A Contribution of Imbalance of M1/M2 Monocytes to Osteoclastogenesis

ObjectivesWe investigated the relationships among M1 monocytes, M2 monocytes, osteoclast (OC) differentiation ability, and clinical characteristics in patients with rheumatoid arthritis (RA).MethodsPeripheral blood mononuclear cells (PBMCs) were isolated from RA patients and healthy donors, and we t...

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Bibliographic Details
Main Authors: Shoichi Fukui, Naoki Iwamoto, Ayuko Takatani, Takashi Igawa, Toshimasa Shimizu, Masataka Umeda, Ayako Nishino, Yoshiro Horai, Yasuko Hirai, Tomohiro Koga, Shin-ya Kawashiri, Mami Tamai, Kunihiro Ichinose, Hideki Nakamura, Tomoki Origuchi, Ritsuko Masuyama, Kosuke Kosai, Katsunori Yanagihara, Atsushi Kawakami
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
monocytes
anticitrullinated protein antibody
osteoclasts
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01958/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01958/full

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