Objective response to immune checkpoint inhibitor therapy in NRAS-mutant melanoma: A systematic review and meta-analysis

Objective response to immune checkpoint inhibitor therapy in NRAS-mutant melanoma: A systematic review and meta-analysis

IntroductionNRAS mutations are common in melanoma and confer a worse prognosis. Although most patients with metastatic melanoma receive immune checkpoint inhibitors (ICIs), the impact of NRAS mutational status on their efficacy remains under debate.MethodsWe performed a comprehensive literature sear...

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Bibliographic Details
Main Authors: Zachary J. Jaeger, Neel S. Raval, Natalia K. A. Maverakis, David Y. Chen, George Ansstas, Angela Hardi, Lynn A. Cornelius
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Medicine
Subjects:
metastatic melanoma
cutaneous melanoma
immunotherapy
checkpoint inhibitor
NRAS
objective response rate
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1090737/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1090737/full

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