Estetrol/GPER/SERPINB2 transduction signaling inhibits the motility of triple-negative breast cancer cells

Estetrol/GPER/SERPINB2 transduction signaling inhibits the motility of triple-negative breast cancer cells

Abstract Background Estetrol (E4) is a natural estrogen produced by the fetal liver during pregnancy. Due to its favorable safety profile, E4 was recently approved as estrogenic component of a new combined oral contraceptive. E4 is a selective ligand of estrogen receptor (ER)α and ERβ, but its bindi...

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Bibliographic Details
Main Authors: Francesca Cirillo, Asia Spinelli, Marianna Talia, Domenica Scordamaglia, Maria Francesca Santolla, Fedora Grande, Bruno Rizzuti, Marcello Maggiolini, Céline Gérard, Rosamaria Lappano
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Journal of Translational Medicine
Subjects:
Estetrol (E4)
G protein-coupled estrogen receptor (GPER)
SERPINB2
Triple-negative breast cancer (TNBC)
Online Access:https://doi.org/10.1186/s12967-024-05269-6

Internet

https://doi.org/10.1186/s12967-024-05269-6

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