Monophosphate Derivatives of Luteolin and Apigenin as Efficient Precursors with Improved Oral Bioavailability in Rats

Monophosphate Derivatives of Luteolin and Apigenin as Efficient Precursors with Improved Oral Bioavailability in Rats

Luteolin (Lut) and apigenin (Apn), flavones present in various edible plants, exhibit diverse antioxidant and pharmacological activities but have limited in vivo efficacy due to low water solubility and poor bioavailability. Here, we generated luteolin and apigenin monophosphate derivatives (LutPs a...

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Bibliographic Details
Main Authors: Sydney Wu, Shang-Ta Wang, Guan-Yuan Chen, Chen Hsu, Yi-Hsin Chen, Hsin-Ya Tsai, Te-I Weng, Chien-Li Chen, Yi-Fang Wu, Nan-Wei Su
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Antioxidants
Subjects:
bioconversion
flavone
<i>Bacillus subtilis</i>
bioavailability
phosphorylation
phosphate prodrug
Online Access:https://www.mdpi.com/2076-3921/13/12/1530

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https://www.mdpi.com/2076-3921/13/12/1530

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