Short-Term and Long-Term Carcinogenic Effects of Food Contaminants (4-Hydroxynonenal and Pesticides) on Colorectal Human Cells: Involvement of Genotoxic and Non-Genomic Mechanisms

Short-Term and Long-Term Carcinogenic Effects of Food Contaminants (4-Hydroxynonenal and Pesticides) on Colorectal Human Cells: Involvement of Genotoxic and Non-Genomic Mechanisms

To investigate environmental impacts upon colorectal carcinogenesis (CRC) by diet, we assessed two western diet food contaminants: 4-hydroxynonenal (HNE), a major lipid peroxidation product neoformed during digestion, and a mixture of pesticides. We used human colonic cell lines ectopically elicitin...

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Bibliographic Details
Main Authors: Liana C. Arnaud, Thierry Gauthier, Augustin Le Naour, Saleha Hashim, Nathalie Naud, Jerry W. Shay, Fabrice H. Pierre, Elisa Boutet-Robinet, Laurence Huc
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
colorectal carcinogenesis
pesticides
4-hydroxynonenal
genotoxicity
non genomic carcinogenesis
genetic susceptibility
Online Access:https://www.mdpi.com/2072-6694/13/17/4337

Internet

https://www.mdpi.com/2072-6694/13/17/4337

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