Aberrant Cellular Glycosylation May Increase the Ability of Influenza Viruses to Escape Host Immune Responses through Modification of the Viral Glycome

Aberrant Cellular Glycosylation May Increase the Ability of Influenza Viruses to Escape Host Immune Responses through Modification of the Viral Glycome

ABSTRACT Individuals with metabolic dysregulation of cellular glycosylation often experience severe influenza disease, with a poor immune response to the virus and low vaccine efficacy. Here, we investigate the consequences of aberrant cellular glycosylation for the glycome and the biology of influe...

Full description

Bibliographic Details
Main Authors: Irina V. Alymova, John F. Cipollo, Lisa M. Parsons, Nedzad Music, Ram P. Kamal, Wen-Pin Tzeng, Cynthia S. Goldsmith, Joseph N. Contessa, Kevan L. Hartshorn, Jason R. Wilson, Hui Zeng, Shane Gansebom, Ian A. York
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:mBio
Subjects:
virus
influenza
hemagglutinin
neuraminidase
pathogenicity
NGI-1
Online Access:https://journals.asm.org/doi/10.1128/mbio.02983-21

Internet

https://journals.asm.org/doi/10.1128/mbio.02983-21

Similar Items