Tumoricidal Potential of Novel Amino-1,10-phenanthroline Derived Imine Ligands: Chemical Preparation, Structure, and Biological Investigations

Tumoricidal Potential of Novel Amino-1,10-phenanthroline Derived Imine Ligands: Chemical Preparation, Structure, and Biological Investigations

Herein we report the synthesis and structural elucidation of two novel imine-based ligands, 2-(1,10-phenanthrolin-5-yl)imino)methyl)-5-bromophenol (PIB) and <i>N</i>-(1,10-phenanthrolin-5-yl)-1-(thiophen-3-yl)methanimine (PTM) ligands. An in vitro cytotoxicity assay of the synthesized mo...

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Bibliographic Details
Main Authors: Kollur Shiva Prasad, Renjith Raveendran Pillai, Chandan Shivamallu, Shashanka K. Prasad, Anisha S. Jain, Sushma Pradeep, Stevan Armaković, Sanja J. Armaković, Chandrashekar Srinivasa, Sharadadevi Kallimani, Raghavendra G. Amachawadi, Veena Malligere Ankegowda, Najat Marraiki, Abdallah M. Elgorban, Asad Syed
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molecules
Subjects:
Phenanthrolin-5-yl
selective cytotoxicity
MD simulations
computational analysis
Online Access:https://www.mdpi.com/1420-3049/25/12/2865

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https://www.mdpi.com/1420-3049/25/12/2865

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