H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for H3K4me1/2 on enhancers remain elusive. Furthermore, how these enzymes function on enhancers to regulate cel...

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Bibliographic Details
Main Authors: Ji-Eun Lee, Chaochen Wang, Shiliyang Xu, Young-Wook Cho, Lifeng Wang, Xuesong Feng, Anne Baldridge, Vittorio Sartorelli, Lenan Zhuang, Weiqun Peng, Kai Ge
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-12-01
Series:eLife
Subjects:
enhancer chromatin modification
MLL4
H3K4me1
KMT2D
enhancer activation
H3K27ac
Online Access:https://elifesciences.org/articles/01503

Internet

https://elifesciences.org/articles/01503

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