Merkel Cell Polyomavirus Large T Antigen Unique Domain Regulates Its Own Protein Stability and Cell Growth

Merkel cell polyomavirus (MCV) is the only known human oncogenic virus in the polyomaviridae family and the etiological agent of most Merkel cell carcinomas (MCC). MCC is an aggressive and highly metastatic skin cancer with a propensity for recurrence and poor prognosis. Large tumor antigen (LT), is...

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Bibliographic Details
Main Authors: Nnenna Nwogu, Luz E. Ortiz, Hyun Jin Kwun
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/12/9/1043