Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone that exerts crucial metabolic functions by binding and activating its cognate receptor, GIPR. As an important therapeutic target, GIPR has been subjected to intensive structural studies without success. Here, we report the cryo-...

Full description

Bibliographic Details
Main Authors: Fenghui Zhao, Chao Zhang, Qingtong Zhou, Kaini Hang, Xinyu Zou, Yan Chen, Fan Wu, Qidi Rao, Antao Dai, Wanchao Yin, Dan-Dan Shen, Yan Zhang, Tian Xia, Raymond C Stevens, H Eric Xu, Dehua Yang, Lihua Zhao, Ming-Wei Wang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
glucose-dependent insulinotropic polypeptide receptor
cryo-electron microscopy
G protein-coupled receptor
ligand recognition
Online Access:https://elifesciences.org/articles/68719

Internet

https://elifesciences.org/articles/68719

Similar Items