Klotho induces insulin resistance possibly through interference with GLUT4 translocation and activation of Akt, GSK3β, and PFKfβ3 in 3T3-L1 adipocyte cells

Klotho induces insulin resistance possibly through interference with GLUT4 translocation and activation of Akt, GSK3β, and PFKfβ3 in 3T3-L1 adipocyte cells

Klotho is considered as an anti-aging factor inducing insulin resistance and involved in type 2 diabetes. However, mechanisms by which klotho induces insulin resistance remain to be understood. Thus, in this study, we aimed to evaluate possible interference points of klotho with insulin signaling pa...

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Bibliographic Details
Main Authors: Mohamad Hasannejad, Seyed Ziaaldin Samsamshariat, Armita Esmaili, Ali Jahanian-Najafabadi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
adipocyte; insulin resistance; klotho; 3t3-l1 cell
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2019;volume=14;issue=4;spage=369;epage=377;aulast=Hasannejad

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http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2019;volume=14;issue=4;spage=369;epage=377;aulast=Hasannejad

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