Mouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment

Mouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment

Dravet syndrome is an intractable epileptic encephalopathy characterized by early onset epileptic seizures followed by cognitive decline, hyperactivity, autistic behaviors and ataxia. Most Dravet syndrome patients possess heterozygous mutations of SCN1A gene encoding voltage-gated sodium channel αI...

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Bibliographic Details
Main Authors: Susumu Ito, Ikuo Ogiwara, Kazuyuki Yamada, Hiroyuki Miyamoto, Takao K. Hensch, Makiko Osawa, Kazuhiro Yamakawa
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Neurobiology of Disease
Subjects:
SCN1A
Lowered sociability
Spatial learning deficit
Parvalbumin
Interneuron
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002902

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http://www.sciencedirect.com/science/article/pii/S0969996112002902

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