An integrative analysis of single-cell and bulk transcriptome and bidirectional mendelian randomization analysis identified C1Q as a novel stimulated risk gene for Atherosclerosis

An integrative analysis of single-cell and bulk transcriptome and bidirectional mendelian randomization analysis identified C1Q as a novel stimulated risk gene for Atherosclerosis

BackgroundThe role of complement component 1q (C1Q) related genes on human atherosclerotic plaques (HAP) is less known. Our aim is to establish C1Q associated hub genes using single-cell RNA sequencing (scRNA-seq) and bulk RNA analysis to diagnose and predict HAP patients more effectively and invest...

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Bibliographic Details
Main Authors: Hong-Kai Cui, Chao-Jie Tang, Yu Gao, Zi-Ang Li, Jian Zhang, Yong-Dong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
atherosclerotic plaque (AP)
ScRNA-seq
Mendelian randomization (MR)
complement component 1q (C1q)
LASSO
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1289223/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1289223/full

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