Preconditioning or Postconditioning with 8-Br-cAMP-AM Protects the Heart against Regional Ischemia and Reperfusion: A Role for Mitochondrial Permeability Transition

Preconditioning or Postconditioning with 8-Br-cAMP-AM Protects the Heart against Regional Ischemia and Reperfusion: A Role for Mitochondrial Permeability Transition

The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of...

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Bibliographic Details
Main Authors: Igor Khaliulin, Raimondo Ascione, Leonid N. Maslov, Haitham Amal, M. Saadeh Suleiman
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
cyclic AMP
heart
regional ischaemia
cardioprotection
reperfusion injury
mitochondria permeability transition pore
Online Access:https://www.mdpi.com/2073-4409/10/5/1223

Internet

https://www.mdpi.com/2073-4409/10/5/1223

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