Changes in the gut microbiota of NOD mice in response to an oral Salmonella-based vaccine against type 1 diabetes.

We developed an oral Salmonella-based vaccine that prevents and reverses diabetes in non-obese diabetic (NOD) mice. Related to this, the gastrointestinal tract harbors a complex dynamic population of microorganisms, the gut microbiome, that influences host homeostasis and metabolism. Changes in the...

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Bibliographic Details
Main Authors: Jacob Cobb, Sameh S M Soliman, Mauricio Retuerto, Janine C Quijano, Chris Orr, Mahmoud Ghannoum, Fouad Kandeel, Mohamed I Husseiny
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0285905