Docking Studies and Anti-inflammatory Activity of β-Hydroxy-β-arylpropanoic Acids

Docking Studies and Anti-inflammatory Activity of β-Hydroxy-β-arylpropanoic Acids

The article describes a two-step synthesis of diastereomeric 3-hydroxy-2-methyl-3-(4-biphenylyl)butanoic acids. In the first step an intermediate α-bromo propanoicacid 1-ethoxyethyl ester was synthesized. The second step is a new modified Reformatskyreaction in presence of Zn in tetrahydrofuran (...

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Bibliographic Details
Main Authors: Ivan O. Juranic, Sote M. Vladimirov, Bojan D. Markovic, Zorica D. Juranic, Silva Lj. Dobric, Sanda P. Dilber
Format: Article
Language:English
Published: MDPI AG 2008-03-01
Series:Molecules
Subjects:
β-Hydroxy-β-arylalkanoic acids
Reformatsky reaction
anti-inflammatory activity
molecular docking simulations
COX-2 selective inhibitor
Online Access:http://www.mdpi.com/1420-3049/13/3/603/

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http://www.mdpi.com/1420-3049/13/3/603/

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